Description
Contraindications
Hypersensitivity to letrozole or any of the other components of the drug;
Hormonal reproductive status, including premenopause;
Pregnancy, lactation period;
Age below 18 years.
Caution
Caution should be exercised when using letrozole in patients with severe hepatic impairment (Child-Pugh class C), severe renal impairment (creatinine clearance less than 10 ml/min).
Pregnancy and lactation
In animal studies, letrozole has shown embryo- and fetotoxic effects, as well as teratogenic properties.
Patients with preserved reproductive potential, including perimenopausal and early postmenopausal patients, should be advised to use adequate contraception until a stable postmenopausal hormonal status is established.
The use of the drug during breastfeeding is contraindicated. The patient should be informed of the potential risks of using the drug during breastfeeding.
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