Letrozol Aristo® 2,5 mg

5,34 53,40 

SKU: N/A Category:


Metabolism and excretion

It is metabolised mainly in the liver with cytochrome P450 isoenzymes to the pharmacologically inactive form of the carbinol derivative (4,4′-methanol-dibenzonitrile). Approximately 75 per cent of a dose of letrozole is excreted via the kidneys as the glucuronide of the carbinol derivative, approximately 9 per cent as unidentified metabolites and approximately 6 per cent as unchanged; to a lesser extent, it is excreted via the intestines. The elimination phase half-life (T½) is approximately 48 hours.

Patients in selected age groups: The pharmacokinetic parameters of letrozole do not depend on the age of the patient.

In renal insufficiency, the pharmacokinetics of the drug do not change.

Hepatic impairment: In mild and moderate hepatic impairment (Child-Pugh class A and B), mean AUC values are 37% higher, but do not exceed the range of values obtained for subjects without hepatic impairment. In patients with cirrhosis and severe hepatic impairment (Child-Pugh class C), the AUC increases almost 2-fold and total clearance of letrozole decreases by 47%. However, given the good tolerability of high doses of the drug (5-10 mg/day), no dose adjustment is required.

Additional information

substance active


Amount of substance, mg


formulaire de discharge


1 compressed, mg


Plaquettes thermoformed by package, pieces



Aristo Pharma GmbH

volume de commande

1 blister of 10 compresses, 1 package (10 blisters)


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